diff --git a/contrib/depends/hosts/darwin.mk b/contrib/depends/hosts/darwin.mk
index 58ff5dc32..88f7fc60c 100644
--- a/contrib/depends/hosts/darwin.mk
+++ b/contrib/depends/hosts/darwin.mk
@@ -1,15 +1,25 @@
-OSX_MIN_VERSION=10.13
+OSX_MIN_VERSION=11
 OSX_SDK_VERSION=11.0
 XCODE_VERSION=12.2
 XCODE_BUILD_ID=12B45b
-LD64_VERSION=609
+LD64_VERSION=711
 
 OSX_SDK=$(host_prefix)/native/SDK
 
-darwin_native_toolchain=darwin_sdk native_cctools
+darwin_native_toolchain=darwin_sdk
 
-clang_prog=$(shell $(SHELL) $(.SHELLFLAGS) "command -v clang")
-clangxx_prog=$(shell $(SHELL) $(.SHELLFLAGS) "command -v clang++")
+clang_prog=clang
+clangxx_prog=clang++
+llvm_config_prog=llvm-config
+
+llvm_lib_dir=$(shell $(llvm_config_prog) --libdir)
+
+darwin_AR=llvm-ar
+darwin_DSYMUTIL=dsymutil
+darwin_NM=llvm-nm
+darwin_OBJDUMP=llvm-objdump
+darwin_RANLIB=llvm-ranlib
+darwin_STRIP=llvm-strip
 
 # Flag explanations:
 #
@@ -37,23 +47,23 @@ clangxx_prog=$(shell $(SHELL) $(.SHELLFLAGS) "command -v clang++")
 darwin_CC=env -u C_INCLUDE_PATH -u CPLUS_INCLUDE_PATH \
               -u OBJC_INCLUDE_PATH -u OBJCPLUS_INCLUDE_PATH -u CPATH \
               -u LIBRARY_PATH \
-            $(clang_prog) --target=$(host) -mmacosx-version-min=$(OSX_MIN_VERSION) \
-              -B$(build_prefix)/bin -mlinker-version=$(LD64_VERSION) \
-              -isysroot$(OSX_SDK) \
+            $(clang_prog) --target=$(host)  \
+              -B$(build_prefix)/bin \
               -isysroot$(OSX_SDK) -nostdlibinc \
               -iwithsysroot/usr/include -iframeworkwithsysroot/System/Library/Frameworks
 
 darwin_CXX=env -u C_INCLUDE_PATH -u CPLUS_INCLUDE_PATH \
                -u OBJC_INCLUDE_PATH -u OBJCPLUS_INCLUDE_PATH -u CPATH \
                -u LIBRARY_PATH \
-             $(clangxx_prog) --target=$(host) -mmacosx-version-min=$(OSX_MIN_VERSION) \
-               -B$(build_prefix)/bin -mlinker-version=$(LD64_VERSION) \
+             $(clangxx_prog) --target=$(host) \
+               -B$(build_prefix)/bin \
                -isysroot$(OSX_SDK) -nostdlibinc \
                -iwithsysroot/usr/include/c++/v1 \
                -iwithsysroot/usr/include -iframeworkwithsysroot/System/Library/Frameworks
 
-darwin_CFLAGS=-pipe
-darwin_CXXFLAGS=$(darwin_CFLAGS)
+darwin_CFLAGS=-pipe -mmacosx-version-min=$(OSX_MIN_VERSION) -mlinker-version=$(LD64_VERSION)
+darwin_CXXFLAGS=-pipe -mmacosx-version-min=$(OSX_MIN_VERSION) -mlinker-version=$(LD64_VERSION)
+darwin_LDFLAGS=-Wl,-platform_version,macos,$(OSX_MIN_VERSION),$(OSX_SDK_VERSION) -Wl,-no_adhoc_codesign -fuse-ld=lld
 darwin_ARFLAGS=cr
 
 darwin_release_CFLAGS=-O2
diff --git a/contrib/depends/packages/boost.mk b/contrib/depends/packages/boost.mk
index 3f7fba1f1..2e866cee0 100644
--- a/contrib/depends/packages/boost.mk
+++ b/contrib/depends/packages/boost.mk
@@ -12,15 +12,13 @@ $(package)_config_opts=--layout=tagged --build-type=complete --user-config=user-
 $(package)_config_opts+=threading=multi link=static -sNO_BZIP2=1 -sNO_ZLIB=1
 $(package)_config_opts_linux=threadapi=pthread runtime-link=shared
 $(package)_config_opts_android=threadapi=pthread runtime-link=static target-os=android
-$(package)_config_opts_darwin=--toolset=darwin runtime-link=shared
+$(package)_config_opts_darwin=runtime-link=shared target-os=darwin
 $(package)_config_opts_mingw32=binary-format=pe target-os=windows threadapi=win32 runtime-link=static
 $(package)_config_opts_x86_64_mingw32=address-model=64
 $(package)_config_opts_i686_mingw32=address-model=32
 $(package)_config_opts_i686_linux=address-model=32 architecture=x86
 $(package)_toolset_$(host_os)=gcc
 $(package)_archiver_$(host_os)=$($(package)_ar)
-$(package)_toolset_darwin=darwin
-$(package)_archiver_darwin=$($(package)_libtool)
 $(package)_config_libraries_$(host_os)="chrono,filesystem,program_options,system,thread,test,date_time,regex,serialization"
 $(package)_config_libraries_mingw32="chrono,filesystem,program_options,system,thread,test,date_time,regex,serialization,locale"
 $(package)_cxxflags+=-std=c++11
diff --git a/contrib/depends/packages/libusb.mk b/contrib/depends/packages/libusb.mk
index 53c91134c..a4b24f826 100644
--- a/contrib/depends/packages/libusb.mk
+++ b/contrib/depends/packages/libusb.mk
@@ -3,8 +3,10 @@ $(package)_version=1.0.27
 $(package)_download_path=https://github.com/libusb/libusb/releases/download/v$($(package)_version)
 $(package)_file_name=$(package)-$($(package)_version).tar.bz2
 $(package)_sha256_hash=ffaa41d741a8a3bee244ac8e54a72ea05bf2879663c098c82fc5757853441575
+$(package)_patches=fix-c11-check.patch
 
 define $(package)_preprocess_cmds
+  patch -p1 < $($(package)_patch_dir)/fix-c11-check.patch && \
   cp -f $(BASEDIR)/config.guess $(BASEDIR)/config.sub . && \
   autoreconf -i
 endef
diff --git a/contrib/depends/packages/native_cctools.mk b/contrib/depends/packages/native_cctools.mk
deleted file mode 100644
index a019b1649..000000000
--- a/contrib/depends/packages/native_cctools.mk
+++ /dev/null
@@ -1,37 +0,0 @@
-package=native_cctools
-$(package)_version=04663295d0425abfac90a42440a7ec02d7155fea
-$(package)_download_path=https://github.com/tpoechtrager/cctools-port/archive
-$(package)_download_file=$($(package)_version).tar.gz
-$(package)_file_name=$(package)-$($(package)_version).tar.gz
-$(package)_sha256_hash=70a7189418c2086d20c299c5d59250cf5940782c778892ccc899c66516ed240e
-$(package)_build_subdir=cctools
-$(package)_patches=no-build-date.patch
-$(package)_dependencies=native_libtapi
-
-define $(package)_set_vars
-$(package)_config_opts=--target=$(host) --disable-lto-support --with-libtapi=$(host_prefix)
-$(package)_ldflags+=-Wl,-rpath=\\$$$$$$$$\$$$$$$$$ORIGIN/../lib
-$(package)_cc=$(clang_prog)
-$(package)_cxx=$(clangxx_prog)
-endef
-
-define $(package)_preprocess_cmds
-  cp -f $(BASEDIR)/config.guess $(BASEDIR)/config.sub cctools
-endef
-
-define $(package)_preprocess_cmds
-  patch -p1 < $($(package)_patch_dir)/no-build-date.patch
-endef
-
-define $(package)_config_cmds
-  $($(package)_autoconf)
-endef
-
-define $(package)_build_cmds
-  $(MAKE)
-endef
-
-define $(package)_stage_cmds
-  $(MAKE) DESTDIR=$($(package)_staging_dir) install && \
-  cp $($(package)_extract_dir)/cctools/misc/install_name_tool $($(package)_staging_prefix_dir)/bin/
-endef
diff --git a/contrib/depends/packages/native_libtapi.mk b/contrib/depends/packages/native_libtapi.mk
deleted file mode 100644
index 36234a001..000000000
--- a/contrib/depends/packages/native_libtapi.mk
+++ /dev/null
@@ -1,19 +0,0 @@
-package=native_libtapi
-$(package)_version=664b8414f89612f2dfd35a9b679c345aa5389026
-$(package)_download_path=https://github.com/tpoechtrager/apple-libtapi/archive
-$(package)_download_file=$($(package)_version).tar.gz
-$(package)_file_name=$(package)-$($(package)_version).tar.gz
-$(package)_sha256_hash=62e419c12d1c9fad67cc1cd523132bc00db050998337c734c15bc8d73cc02b61
-$(package)_patches=no_embed_git_rev.patch
-
-define $(package)_preprocess_cmds
-  patch -p1 -i $($(package)_patch_dir)/no_embed_git_rev.patch
-endef
-
-define $(package)_build_cmds
-  CC=$(clang_prog) CXX=$(clangxx_prog) INSTALLPREFIX=$($(package)_staging_prefix_dir) ./build.sh
-endef
-
-define $(package)_stage_cmds
-  ./install.sh
-endef
diff --git a/contrib/depends/packages/packages.mk b/contrib/depends/packages/packages.mk
index cb4e8e228..68935608b 100644
--- a/contrib/depends/packages/packages.mk
+++ b/contrib/depends/packages/packages.mk
@@ -24,5 +24,5 @@ mingw32_packages = $(hardware_packages)
 mingw32_native_packages = $(hardware_native_packages)
 
 ifneq ($(build_os),darwin)
-darwin_native_packages += darwin_sdk native_cctools native_libtapi
+darwin_native_packages += darwin_sdk
 endif
diff --git a/contrib/depends/patches/libusb/fix-c11-check.patch b/contrib/depends/patches/libusb/fix-c11-check.patch
new file mode 100644
index 000000000..93b005763
--- /dev/null
+++ b/contrib/depends/patches/libusb/fix-c11-check.patch
@@ -0,0 +1,22 @@
+diff --git a/configure.ac b/configure.ac
+index 6dc7c698..eebe10a1 100644
+--- a/configure.ac
++++ b/configure.ac
+@@ -46,7 +46,7 @@ dnl note that we don't just check if the compiler accepts '-std=x11'
+ dnl but also that it supports the _Thread_local keyword because some compilers
+ dnl (e.g. gcc 4.8) accept the command line option but do not implement TLS
+ saved_CFLAGS="${CFLAGS}"
+-CFLAGS="-std=gnu11"
++CFLAGS="${saved_CFLAGS} -std=gnu11"
+ AC_MSG_CHECKING([if $CC supports -std=gnu11])
+ AC_COMPILE_IFELSE([AC_LANG_PROGRAM([_Thread_local int x;], [x = 42;])],
+ 	[AC_MSG_RESULT([yes])
+@@ -55,7 +55,7 @@ AC_COMPILE_IFELSE([AC_LANG_PROGRAM([_Thread_local int x;], [x = 42;])],
+ 	 c_dialect=])
+ if test "x$c_dialect" != xgnu; then
+ 	dnl fallback check for -std=c11 compiler support (required)
+-	CFLAGS="-std=c11"
++	CFLAGS="${saved_CFLAGS} -std=c11"
+ 	AC_MSG_CHECKING([if $CC supports -std=c11])
+ 	AC_COMPILE_IFELSE([AC_LANG_PROGRAM([_Thread_local int x;], [x = 42;])],
+ 		[AC_MSG_RESULT([yes])],
diff --git a/contrib/depends/toolchain.cmake.in b/contrib/depends/toolchain.cmake.in
index eb0da1877..1847dbd82 100644
--- a/contrib/depends/toolchain.cmake.in
+++ b/contrib/depends/toolchain.cmake.in
@@ -67,12 +67,16 @@ if(CMAKE_SYSTEM_NAME STREQUAL "Darwin")
   SET(_CMAKE_TOOLCHAIN_PREFIX @prefix@/native/bin/${CONF_TRIPLE}-)
   SET(CMAKE_C_COMPILER @CC@)
   SET(CMAKE_C_COMPILER_TARGET ${CLANG_TARGET})
-  SET(CMAKE_C_FLAGS_INIT -B${_CMAKE_TOOLCHAIN_PREFIX})
+  SET(CMAKE_C_FLAGS "@CFLAGS@")
   SET(CMAKE_CXX_COMPILER @CXX@ -stdlib=libc++)
   SET(CMAKE_CXX_COMPILER_TARGET ${CLANG_TARGET})
-  SET(CMAKE_CXX_FLAGS_INIT -B${_CMAKE_TOOLCHAIN_PREFIX})
+  SET(CMAKE_CXX_FLAGS "@CXXFLAGS@")
+  SET(CMAKE_EXE_LINKER_FLAGS "@LDFLAGS@")
+  SET(CMAKE_MODULE_LINKER_FLAGS "@LDFLAGS@")
+  SET(CMAKE_SHARED_LINKER_FLAGS "@LDFLAGS@")
+  SET(CMAKE_INSTALL_NAME_TOOL llvm-install-name-tool)
   SET(CMAKE_ASM_COMPILER clang)
-  SET(CMAKE_ASM-ATT_COMPILER as)
+  SET(CMAKE_ASM-ATT_COMPILER llvm-as)
   SET(CMAKE_ASM_COMPILER_TARGET ${CLANG_TARGET})
   SET(CMAKE_ASM-ATT_COMPILER_TARGET ${CLANG_TARGET})
   SET(APPLE True)
@@ -82,8 +86,6 @@ if(CMAKE_SYSTEM_NAME STREQUAL "Darwin")
   SET(CMAKE_OSX_SYSROOT "@prefix@/native/SDK/")
   SET(CMAKE_OSX_DEPLOYMENT_TARGET "10.13")
   SET(CMAKE_CXX_STANDARD 17)
-  SET(LLVM_ENABLE_PIC OFF)
-  SET(LLVM_ENABLE_PIE OFF)
 elseif(CMAKE_SYSTEM_NAME STREQUAL "Android")
   SET(ANDROID TRUE)
   if(ARCHITECTURE STREQUAL "arm")
diff --git a/contrib/guix/libexec/build.sh b/contrib/guix/libexec/build.sh
index be2c937fb..c70defa4e 100644
--- a/contrib/guix/libexec/build.sh
+++ b/contrib/guix/libexec/build.sh
@@ -165,15 +165,6 @@ done
 
 # Disable Guix ld auto-rpath behavior
 case "$HOST" in
-    *darwin*)
-        # The auto-rpath behavior is necessary for darwin builds as some native
-        # tools built by depends refer to and depend on Guix-built native
-        # libraries
-        #
-        # After the native packages in depends are built, the ld wrapper should
-        # no longer affect our build, as clang would instead reach for
-        # x86_64-apple-darwin-ld from cctools
-        ;;
     *android*)
         ;;
     *) export GUIX_LD_WRAPPER_DISABLE_RPATH=yes ;;
@@ -220,16 +211,6 @@ export GLIBC_DYNAMIC_LINKER=${glibc_dynamic_linker}
 # Environment variables for determinism
 export TAR_OPTIONS="--owner=0 --group=0 --numeric-owner --mtime='@${SOURCE_DATE_EPOCH}' --sort=name"
 export TZ="UTC"
-case "$HOST" in
-    *darwin*)
-        # cctools AR, unlike GNU binutils AR, does not have a deterministic mode
-        # or a configure flag to enable determinism by default, it only
-        # understands if this env-var is set or not. See:
-        #
-        # https://github.com/tpoechtrager/cctools-port/blob/55562e4073dea0fbfd0b20e0bf69ffe6390c7f97/cctools/ar/archive.c#L334
-        export ZERO_AR_DATE=yes
-        ;;
-esac
 
 ####################
 # Depends Building #
diff --git a/contrib/guix/manifest.scm b/contrib/guix/manifest.scm
index 301459c4d..3899df130 100644
--- a/contrib/guix/manifest.scm
+++ b/contrib/guix/manifest.scm
@@ -307,6 +307,7 @@ chain for " target " development."))
           ((string-contains target "darwin")
            (list
              gcc-toolchain-10
-             clang-toolchain-11
-             binutils))
+             clang-toolchain-17
+             lld-17
+             (make-lld-wrapper lld-17 #:lld-as-ld? #t)))
           (else '())))))
diff --git a/contrib/guix/patches/fix-c11-check.patch b/contrib/guix/patches/fix-c11-check.patch
new file mode 100644
index 000000000..93b005763
--- /dev/null
+++ b/contrib/guix/patches/fix-c11-check.patch
@@ -0,0 +1,22 @@
+diff --git a/configure.ac b/configure.ac
+index 6dc7c698..eebe10a1 100644
+--- a/configure.ac
++++ b/configure.ac
+@@ -46,7 +46,7 @@ dnl note that we don't just check if the compiler accepts '-std=x11'
+ dnl but also that it supports the _Thread_local keyword because some compilers
+ dnl (e.g. gcc 4.8) accept the command line option but do not implement TLS
+ saved_CFLAGS="${CFLAGS}"
+-CFLAGS="-std=gnu11"
++CFLAGS="${saved_CFLAGS} -std=gnu11"
+ AC_MSG_CHECKING([if $CC supports -std=gnu11])
+ AC_COMPILE_IFELSE([AC_LANG_PROGRAM([_Thread_local int x;], [x = 42;])],
+ 	[AC_MSG_RESULT([yes])
+@@ -55,7 +55,7 @@ AC_COMPILE_IFELSE([AC_LANG_PROGRAM([_Thread_local int x;], [x = 42;])],
+ 	 c_dialect=])
+ if test "x$c_dialect" != xgnu; then
+ 	dnl fallback check for -std=c11 compiler support (required)
+-	CFLAGS="-std=c11"
++	CFLAGS="${saved_CFLAGS} -std=c11"
+ 	AC_MSG_CHECKING([if $CC supports -std=c11])
+ 	AC_COMPILE_IFELSE([AC_LANG_PROGRAM([_Thread_local int x;], [x = 42;])],
+ 		[AC_MSG_RESULT([yes])],