diff --git a/src/backend/cpu/CpuWorker.cpp b/src/backend/cpu/CpuWorker.cpp
index 39e46f6d6..3eb6e4683 100644
--- a/src/backend/cpu/CpuWorker.cpp
+++ b/src/backend/cpu/CpuWorker.cpp
@@ -77,8 +77,11 @@ xmrig::CpuWorker<N>::CpuWorker(size_t id, const CpuLaunchData &data) :
 {
 #   ifdef XMRIG_ALGO_CN_HEAVY
     // cn-heavy optimization for Zen3 CPUs
-    const bool is_vermeer = (Cpu::info()->arch() == ICpuInfo::ARCH_ZEN3) && (Cpu::info()->model() == 0x21);
-    if ((N == 1) && (m_av == CnHash::AV_SINGLE) && (m_algorithm.family() == Algorithm::CN_HEAVY) && (m_assembly != Assembly::NONE) && is_vermeer) {
+    const auto arch = Cpu::info()->arch();
+    const uint32_t model = Cpu::info()->model();
+    const bool is_vermeer = (arch == ICpuInfo::ARCH_ZEN3) && (model == 0x21);
+    const bool is_raphael = (arch == ICpuInfo::ARCH_ZEN4) && (model == 0x61);
+    if ((N == 1) && (m_av == CnHash::AV_SINGLE) && (m_algorithm.family() == Algorithm::CN_HEAVY) && (m_assembly != Assembly::NONE) && (is_vermeer || is_raphael)) {
         std::lock_guard<std::mutex> lock(cn_heavyZen3MemoryMutex);
         if (!cn_heavyZen3Memory) {
             // Round up number of threads to the multiple of 8
diff --git a/src/backend/cpu/interfaces/ICpuInfo.h b/src/backend/cpu/interfaces/ICpuInfo.h
index f2b56009a..387f319b1 100644
--- a/src/backend/cpu/interfaces/ICpuInfo.h
+++ b/src/backend/cpu/interfaces/ICpuInfo.h
@@ -45,19 +45,21 @@ public:
         ARCH_ZEN,
         ARCH_ZEN_PLUS,
         ARCH_ZEN2,
-        ARCH_ZEN3
+        ARCH_ZEN3,
+        ARCH_ZEN4
     };
 
     enum MsrMod : uint32_t {
         MSR_MOD_NONE,
         MSR_MOD_RYZEN_17H,
         MSR_MOD_RYZEN_19H,
+        MSR_MOD_RYZEN_19H_ZEN4,
         MSR_MOD_INTEL,
         MSR_MOD_CUSTOM,
         MSR_MOD_MAX
     };
 
-#   define MSR_NAMES_LIST "none", "ryzen_17h", "ryzen_19h", "intel", "custom"
+#   define MSR_NAMES_LIST "none", "ryzen_17h", "ryzen_19h", "ryzen_19h_zen4", "intel", "custom"
 
     enum Flag : uint32_t {
         FLAG_AES,
diff --git a/src/backend/cpu/platform/BasicCpuInfo.cpp b/src/backend/cpu/platform/BasicCpuInfo.cpp
index 0f81ae254..0680d1bf8 100644
--- a/src/backend/cpu/platform/BasicCpuInfo.cpp
+++ b/src/backend/cpu/platform/BasicCpuInfo.cpp
@@ -64,7 +64,7 @@ static_assert(kCpuFlagsSize == ICpuInfo::FLAG_MAX, "kCpuFlagsSize and FLAG_MAX m
 
 
 #ifdef XMRIG_FEATURE_MSR
-constexpr size_t kMsrArraySize                                  = 5;
+constexpr size_t kMsrArraySize                                  = 6;
 static const std::array<const char *, kMsrArraySize> msrNames   = { MSR_NAMES_LIST };
 static_assert(kMsrArraySize == ICpuInfo::MSR_MOD_MAX, "kMsrArraySize and MSR_MOD_MAX mismatch");
 #endif
@@ -250,8 +250,14 @@ xmrig::BasicCpuInfo::BasicCpuInfo() :
                     break;
 
                 case 0x19:
-                    m_arch = ARCH_ZEN3;
-                    m_msrMod = MSR_MOD_RYZEN_19H;
+                    if (m_model == 0x61) {
+                        m_arch = ARCH_ZEN4;
+                        m_msrMod = MSR_MOD_RYZEN_19H_ZEN4;
+                    }
+                    else {
+                        m_arch = ARCH_ZEN3;
+                        m_msrMod = MSR_MOD_RYZEN_19H;
+                    }
                     break;
 
                 default:
diff --git a/src/crypto/cn/CnHash.cpp b/src/crypto/cn/CnHash.cpp
index 9fbccd83e..4b4b006f3 100644
--- a/src/crypto/cn/CnHash.cpp
+++ b/src/crypto/cn/CnHash.cpp
@@ -407,8 +407,12 @@ xmrig::cn_hash_fun xmrig::CnHash::fn(const Algorithm &algorithm, AlgoVariant av,
     }
 
 #   ifdef XMRIG_ALGO_CN_HEAVY
-    // cn-heavy optimization for Zen3 CPUs
-    if ((av == AV_SINGLE) && (assembly != Assembly::NONE) && (Cpu::info()->arch() == ICpuInfo::ARCH_ZEN3) && (Cpu::info()->model() == 0x21)) {
+    // cn-heavy optimization for Zen3/Zen4 CPUs
+    const auto arch = Cpu::info()->arch();
+    const uint32_t model = Cpu::info()->model();
+    const bool is_vermeer = (arch == ICpuInfo::ARCH_ZEN3) && (model == 0x21);
+    const bool is_raphael = (arch == ICpuInfo::ARCH_ZEN4) && (model == 0x61);
+    if ((av == AV_SINGLE) && (assembly != Assembly::NONE) && (is_vermeer || is_raphael)) {
         switch (algorithm.id()) {
         case Algorithm::CN_HEAVY_0:
             return cryptonight_single_hash<Algorithm::CN_HEAVY_0, false, 3>;
diff --git a/src/crypto/randomx/jit_compiler_x86.cpp b/src/crypto/randomx/jit_compiler_x86.cpp
index 93e8c18fe..7d2603e5e 100644
--- a/src/crypto/randomx/jit_compiler_x86.cpp
+++ b/src/crypto/randomx/jit_compiler_x86.cpp
@@ -262,6 +262,10 @@ namespace randomx {
 						// AVX2 init is faster on Zen3
 						initDatasetAVX2 = true;
 						break;
+					case xmrig::ICpuInfo::ARCH_ZEN4:
+						// AVX2 init is slower on Zen4
+						initDatasetAVX2 = false;
+						break;
 					}
 				}
 			}
diff --git a/src/crypto/rx/RxConfig.cpp b/src/crypto/rx/RxConfig.cpp
index 1cd6f6eb1..362876071 100644
--- a/src/crypto/rx/RxConfig.cpp
+++ b/src/crypto/rx/RxConfig.cpp
@@ -58,12 +58,13 @@ static const std::array<const char *, RxConfig::ModeMax> modeNames = { "auto", "
 
 
 #ifdef XMRIG_FEATURE_MSR
-constexpr size_t kMsrArraySize = 5;
+constexpr size_t kMsrArraySize = 6;
 
 static const std::array<MsrItems, kMsrArraySize> msrPresets = {
     MsrItems(),
     MsrItems{{ 0xC0011020, 0ULL }, { 0xC0011021, 0x40ULL, ~0x20ULL }, { 0xC0011022, 0x1510000ULL }, { 0xC001102b, 0x2000cc16ULL }},
     MsrItems{{ 0xC0011020, 0x0004480000000000ULL }, { 0xC0011021, 0x001c000200000040ULL, ~0x20ULL }, { 0xC0011022, 0xc000000401500000ULL }, { 0xC001102b, 0x2000cc14ULL }},
+    MsrItems{{ 0xC0011020, 0x0004400000000000ULL }, { 0xC0011021, 0x0004000000000040ULL, ~0x20ULL }, { 0xC0011022, 0x8680000401570000ULL }, { 0xC001102b, 0x2040cc10ULL }},
     MsrItems{{ 0x1a4, 0xf }},
     MsrItems()
 };