Without ffile-prefix-map, the debug symbols will contain paths for the guix store which will include the hashes of each package. However, the hash for the same package will differ when on different architectures. In order to be reproducible regardless of the architecture used to build the package, map all guix store prefixes to something fixed, e.g. /usr. --- a/mingw-w64-libraries/winpthreads/Makefile.in +++ b/mingw-w64-libraries/winpthreads/Makefile.in @@ -454,7 +454,7 @@ top_build_prefix = @top_build_prefix@ top_builddir = @top_builddir@ top_srcdir = @top_srcdir@ SUBDIRS = . tests -AM_CFLAGS = -Wall -DWIN32_LEAN_AND_MEAN +AM_CFLAGS = -Wall -DWIN32_LEAN_AND_MEAN $(shell find /gnu/store -maxdepth 1 -mindepth 1 -type d -exec echo -n " -ffile-prefix-map={}=/usr" \;) ACLOCAL_AMFLAGS = -I m4 lib_LTLIBRARIES = libwinpthread.la include_HEADERS = include/pthread.h include/sched.h include/semaphore.h include/pthread_unistd.h include/pthread_time.h include/pthread_compat.h include/pthread_signal.h